R. Abraham b. David Yizhaki (1661–1729), rabbi, halakhic authority, and kabbalist. Born in Jerusalem, he was the grandson of the kabbalist, R. Abraham b. Mordecai Azulai, and son-in-law of R. Abraham Israel Zeevi, a scholar of Hebron. He studied Talmud under R. Moses b. Jonathan Galante, and Kabbalah together with R. Joseph Bialer, grandfather of R. H. J. D. Azulai. He was chief rabbi of Jerusalem, Rishon le-Zion, by 1708, and held the position until his death. He also headed a yeshivah. Among his disciples were R. Moses Hagiz, R. Isaac ha-Kohen Rapoport, and R. Isaac Zerahiah Azulai.

At the beginning of his rabbinate, the inhabitants of Jerusalem suffered from the heavy burden of taxation placed upon them by the government. To ameliorate the situation, R. Yizhaki went to various European countries and to Turkey as an emissary of the community (1709–16). In 1708, as head of the Jerusalem rabbis, he signed a declaration against the Shabbatean Nehemiah Hayon, and during his journey he vigorously opposed the propaganda conducted by Hayon and Miguel Abraham Cardozo. On reaching Amsterdam in 1712 he encouraged R. Moses Hagiz and R. Zevi Ashkenazi (Hakham Zevi) to oppose Hayon, who came to Amsterdam in 1713. On returning to Jerusalem, Yizhaki devoted himself to teaching and writing. Some time later, when the situation of Jerusalem deteriorated and his safety was endangered, he was compelled to flee to Hebron, but later returned to Jerusalem, where he passed on.