R. Moses Isaac ben Samuel Ashkenazi (Tedeschi, Tedesco, 1821–1898) was a translator and teacher. He was born in Trieste and, for most of his life, was engaged in teaching except for a short period (1861) when he served as a rabbi of Spoleto. During his 34 years as a teacher he compiled his Ho'il Moshe, consisting of expositions of most of the books of the Bible (published between 1870 and 1892). This commentary was based both upon traditional commentaries and the modern commentaries from the era of Mendelssohn to Samuel David Luzzatto (with whom he was on friendly terms). In his introduction Tedeschi points to the difference of approach in the various commentaries which were written at different times of his life "but there is no absolute contradition between them and they can be regarded as one corpus." He also published Musar Melakhim (1878), ethical sermons based upon the tractate, Avot; Zekher Rav (1878), of Benjamin Mussafia with an Italian translation and a dictionary called Mafte'ah ha-Shorashim; Ozar Nirdefei Leshon Ivri ("Hebrew synonyms," 1879); Simhat ha-Regel (1886), sermons for the festivals and notes on the Targum of Proverbs, includes his autobiography (pp. 51–61); and Ru'ah Yisrael (1894), a translation from Italian to Hebrew of a collection of studies by Mordecai (Marco) Mortara, rabbi in Mantua.

[כרך ו]: חמש מגלות וספר משלי מבוארים עברית ... ליוורנו, דפוס ישראל קושטא, שנת י'ח'ל' י'ש'ר'א'ל' א'ל' י'י' [תר"ם]. 156, [3] עמ'. בסוף הספר: שיר זהב לכבוד המחבר, מאת ר' ישראל קושטא, המדפיס.