In 1751, the brothers began to place their own names on the title pages of their works. The following year work began on this full size Talmud. The tractate title pages have an ingenious mirror-image monogram comprised of all the letters in the names Jacob and Joseph, but most of the letters are not in mirror-image. In the monogram on the title pages of the first tractates the monogram is printed without an ornamental background, as was done elsewhere. On the title pages of the later tractates, the monogram is printed within an ornate rococo framework. Here too, all the letters in Jacob and Joseph's names are employed, but in a new device.

In 1755, and again between 1759 and 1762, the Proops press was inactive. Rabbinovicz attributes the first interruption to the appearance of the first volumes from the Sulzbach Talmud (first edition 1756-1763; second edition 1766-1770), which caused the Proops to lose many German subscribers. According to Rabbinovicz, the second pause in printing stemmed from a disruption of the Proops' primary market in Poland. Haim Liberman argues that the sole cause of the interruption was competition from the Sulzbach Talmud. The money raised from subscribers was sufficient for only half the edition. To complete the second half of their Talmud the Proops doubled the price to subscribers. This placed a financial burden upon the Jews of Poland, which was relieved by contributions and loans from wealthy Polish Jews. The Talmud was completed in three years.