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Loewe's major contribution is his introduction and commentary to Mendelssohn's German translation of Psalms (1785–88), which includes a study on the structure and style of Hebrew poetry and on the history of ancient Jewish music. He took an active part in Mendelssohn's Bible translation project, writing, in addition to his work on Psalms, commentaries to Ecclesiastes, Jonah, and with Wolfsohn, the Song of Songs. Loewe was the first Haskalah writer to publish original epigrams in the style of the Book of Proverbs, and was the first to translate the Passover Haggadah to German.