R. Moses Isaac ben Samuel Tedeschi (Tedesco; 1821–1898) was a translator, and teacher. He was born in Trieste and engaged in teaching most of his life except for a short period (1861) when he served as a rabbi of Spoleto. R. Tedeschi lectured on Biblical exegesis in the Talmud Torah of his native city, and occasionally delivered sermons on holy days. During his 34 years as a teacher he compiled his Ho'il Moshe, consisting of expositions of most of the books of the Bible (published between 1870 and 1892). This commentary was based both upon traditional commentaries and the modern commentaries from the era of Mendelssohn to Samuel David Luzzatto (with whom he was on friendly terms). In his introduction R. Tedeschi points to the difference of approach in the various commentaries which were written at different times of his life "but there is no absolute contradiction between them and they can be regarded as one corpus." He also published Musar Melakhim (1878), ethical sermons based upon the tractate, Avot; Zekher Rav (1878), of Benjamin Mussafia with an Italian translation and a dictionary called Mafte'ah ha-Shorashim; Ozar Nirdefei Leshon Ivri ("Hebrew synonyms," 1879); and Ru'ah Yisrael (1894), a translation from Italian to Hebrew of a collection of studies by Mordecai (Marco) Mortara, rabbi in Mantua.