For some time, the 800 Jews in Hebron lived in peace with their tens of thousands of Arab neighbors. But on the night of August 23, 1929, the tension simmering within this cauldron of nationalities bubbled over, and for 3 days, Hebron turned into a city of terror and murder. By the time the massacres ended, 67 Jews lay dead and the survivors were relocated to Jerusalem, leaving Hebron barren of Jews for the first time in hundreds of years. The summer of 1929 was one of unrest in Palestine. Jewish-Arab tensions were spurred on by the agitation of the mufti in Jerusalem. Just one day prior to the start of the Hebron massacre, three Jews and three Arabs were killed in Jerusalem when fighting broke out after a Muslim prayer service on the Temple Mount. Arabs spread false rumors throughout their communities, saying that Jews were carrying out "wholesale killings of Arabs." Meanwhile, Jewish immigrants were arriving in Palestine in increasing numbers, further exacerbating the Jewish-Arab conflict. Hebron had, until this time, been outwardly peaceful, although tension hid below the surface. The Sephardi Jewish community in Hebron had lived quietly with its Arab neighbors for centuries. The Sephardi Jews (Jews who were originally from Spain, North Africa and Arab countries) spoke Arabic and had a cultural connection to their Arab neighbors. In the mid-1800s, Ashkenazi (native European) Jews started moving to Hebron and, in 1925, the Slobodka Yeshiva, officially the Yeshiva of Hevron, Knesset Yisrael-Slobodka, was opened. Yeshiva students lived separately from the Sephardi community, and from the Arab population. Due to this isolation, the Arabs viewed them with suspicion and hatred, and identified them as Zionist immigrants. Despite the general suspicion, however, one yeshiva student, Dov Cohen, still recalled being on "very good" terms with the Arab neighbors. He remembered yeshiva boys taking long walks late at night on the outskirts of the city, and not feeling afraid, even though only one British policeman guarded the entire city. On Friday, August 23, 1929, that tranquility was lost. Arab youths started throwing rocks at the yeshiva students. That afternoon, one student, Shmuel Rosenholtz, went to the yeshiva alone. Arab rioters later broke in and killed him, and that was only the beginning. Friday night, Rabbi Ya’acov Slonim’s son invited any fearful Jews to stay in his house. The rabbi was highly regarded in the community, and he had a gun. Many Jews took him up on this offer, and many Jews were eventually murdered there. As early as 8:00 a.m. on Saturday, the Jewish Sabbath, Arabs began to gather en masse. They came in mobs, armed with clubs, knives and axes. While the women and children threw stones, the men ransacked Jewish houses and destroyed Jewish property. With only a single police officer in Hebron, the Arabs entered Jewish courtyards with no opposition.

Rabbi Slonim, who had tried to shelter the Jewish population, was approached by the rioters and offered a deal. If all the Ashkenazi yeshiva students were given over to the Arabs, the rioters would spare the lives of the Sephardi community. Rabbi Slonim refused to turn over the students and was killed on the spot. In the end, 12 Sephardi Jews and 55 Ashkenazi Jews were murdered. A few Arabs did try to help the Jews. Nineteen Arab families saved dozens, maybe even hundreds of Jews. Zmira Mani wrote about an Arab named Abu Id Zaitoun who brought his brother and son to rescue her and her family. The Arab family protected the Manis with their swords, hid them in a cellar along with other Jews who they had saved, and found a policeman to escort them safely to the police station at Beit Romano. The police station turned into a shelter for the Jews that morning of August 24. It also became a synagogue as the Orthodox Jews gathered there and said their morning prayers. As they finished praying, they began to hear noises outside the building. Thousands of Arabs descended from Har Hebron, shouting "Kill the Jews!" in Arabic. They even tried to break down the doors of the station. The Jews were besieged in Beit Romano for three days. Each night, ten men were allowed to leave to attend a funeral in Hebron’s ancient Jewish cemetery for the murdered Jews of the day. When the massacre finally ended, the surviving Jews were forced to leave their home city and resettled in Jerusalem. Some Jewish families tried to move back to Hebron, but were removed by the British authorities in 1936 at the start of the Arab revolt. In 1948, the War of Independence granted Israel statehood, but further cut the Jews off from Hebron, a city that was captured by King Abdullah's Arab Legion and ultimately annexed to Jordan.

When Jews finally gained control of the city in 1967, a small number of massacre survivors again tried to reclaim their old houses. Then defense minister Moshe Dayan supposedly told the survivors that if they returned, they would be arrested, and that they should be patient while the government worked out a solution to get their houses back. Years later, settlers moved to parts of Hebron without the permission of the government, but for those massacre survivors still seeking their original homes, that solution never came.