R. Isaac Kaduri, also spelled Kadouri and Kadourie (d. 2006), was a renowned Sephardic Orthodox Haredi rabbi and kabbalist who devoted his life to Torah study and prayer on behalf of the Jewish people. He taught and practiced the kavanot of the Rashash. His blessings and amulets were also widely sought to cure people of illnesses and infertility. At the time of his death, estimates of his age ranged from 106 to 117.

He was born in Baghdad to R. Katchouri Diba ben `Aziza, a spice trader. No one is certain of the exact year, though two clues are known: he was born on a Shabbat during the intermediate days of Sukkot, known as Chol HaMo'ed. Since Sukkot lasts for nine days, the third to seventh being Chol HaMo'ed, there is always a Shabbat during Sukkot. Thus this indication only excludes the years during which the first and seventh days of Sukkot fell on Shabbat (the second and ninth days can never fall on Shabbat, since the calendar is set so that Yom Kippur never falls on a Friday or a Sunday). A third clue is said to be his name Yitzchak, which is the second of the ushpizin (holy guests of Sukkot) and thus would indicate a birth on the second day... This would contradict the first clue, leaving us with a mystery surrounding his birth.

As a youngster, Kaduri excelled in his studies and began learning Kabbalah while still in his teens, a study that would last his entire life. He was a student of the Ben Ish Chai (R. Yosef Chaim of Baghdad) and studied at the Zilka Yeshivah in Baghdad.

Rabbi Kaduri moved to the British Mandate of Palestine in 1923 upon the advice of the elders of Baghdad, who hoped that his scholarship and piety would stop the incursion of Zionism in the post-World War I state. It was here that he changed his name from Diba to Kaduri. He was drafted into the British Army and worked as a translator. Upon leaving the service, he went to study at the Shoshanim LeDavid Yeshiva for kabbalists from Iraq. There he learned from the leading kabbalists of the time, including R. Yehuda Ftaya, author of Beit Lechem Yehudah, and R. Chaim Ya'akov Sofer, author of Kaf Hachaim. He later immersed himself in regular Talmudic study and rabbinical law in the Porat Yosef Yeshiva in Jerusalem's Old City, where he also studied Kabbalah with the Rosh Yeshivah, R. Ezra Attia, R. Saliman Eliyahu (father of Sephardic Chief Rabbi Mordechai Eliyahu), and other learned rabbis.

In 1934, R. Kaduri and his family moved to the Old City, where the Porat Yosef Yeshivah gave him an apartment nearby with a job of binding the yeshivah's books and copying over rare manuscripts in the yeshivah's library. The books remained in the yeshiva's library, while the copies of manuscripts were stored in Rabbi Kaduri's personal library. Before binding each book, he would study it intently, committing it to memory. He was reputed to have a photographic memory and also mastered the Talmud by heart, including the adjoining Rashi and Tosafot commentaries.

During the period of Arab-Israeli friction that led up to the 1948 war, the Porat Yosef Yeshivah was virtually turned into a fortress against frequent flashes of violence. When the Jewish quarter of the Old City fell to the invading Jordanian Army during the 1948 Arab-Israeli War, the Jordanians set fire to the yeshivah and all surrounding houses, destroying all the books and manuscripts that R. Kaduri could not smuggle out. R. Kaduri went on to study at the Kabbalists' Beit El Yeshiva (Yeshivat HaMekubalim) in Jerusalem. After the passing of the leading kabbalist, R. Efraim Hakohen, in 1989, the remaining kabbalists appointed R. Kaduri as their head.

R. Kaduri did not publish any of the works that he authored on Kabbalah; he allowed only students of Kabbalah to study them. He did publish some articles criticizing those who engage in "practical Kabbalah", the popular dissemination of advice or amulets, often for a price. He also spoke out against the development of cult organizations frequented by pop celebrities. "Kabbalah should not be taught to non-Jews," he explained.