R. Alperstein came to New York in 1881 together with the first wave of immigrants. He served as rabbi of Congregation Adath Jeshurun in New York. Three years later he moved to Chicago, where he remained for 15 years, serving in several synagogues, Congregation Oheb Shalom Bnai Marienpol, Anshei Kovno, and the Suwalker shul. While in Chicago, R. Alperstein published his only book, a commentary on the Jerusalem Talmud, Tractate Bikkurim. After spending two years in St. Paul, Minnesota, R. Alperstein returned to New York in 1901 to become rabbi of the Yagustava shul on Rutgers Street, which enabled him to work together with Rs. Moses Matlin and Judah David Bernstein on the yeshiva named for Rabbi Isaac Elchanan Spektor of Kovno. R. Alperstein campaigned throughout the shteiblach of the Lower East Side, appealing for funds on behalf of RIETS, which began to grow and prosper. He arranged for the school to transfer its program to the Yagustava shul, where he served as rabbi and taught Talmud. By 1905, the year he became rabbi at Congregation Mishkan Israel, approximately 100 students were engaged in Torah study at RIETS. R. Alperstein was also active on behalf of the newly formed Agudat Harabbonim, the Orthodox rabbinical association.

Following his death, his wife founded in his memory the Beth Abraham Home for the Incurably Sick in the Bronx, which at present is the Beth Abraham Hospital, part of the Montefiore-Einstein complex.

גוף הספר (מח דף) הוא ד"ס של הוצאת שיקאגא תרמ"ז (נעשו שינויים בטכסט, כגון בדף כג, א ובדף לד,א). נדפסו מחדש 2 הדפים הראשונים (השער וההסכמות). ו דף: הקדמת המחבר, בשם "פרי גנוסר". התחלת ההקדמה ובסופה הם ד"ס מהוצאת תרמ"ז. [1] דף בסוף הספר: "לוח התיקון". נוספו בו תיקונים רבים. מקצת הטעויות שבלוח הטעויות של הוצאת תרמ"ז תוקנו בגוף הספר.

הסכמות: ר' יוסף דובער הלוי [סולובייצ'יק], בריסק, ראש חדש תמוז תר"ן; ר' יעקב יאסעף, ניו יארק, ב צו תרמ"ט.