Zacuto's published exoteric works include his commentary on the Mishnah, Kol ha-Re-Me-Z; he was known throughout his life as Re-Me-Z, from his initials (Rabbi Moses Zacuto). Part of the work was published in Amsterdam in 1719. R. H. J. D. Azulai, in his Shem ha-Gedolim, noted that the manuscript was twice as long as the printed edition. A collection of halakhic responsa was published in Venice in 1760. A commentary on the Palestinian Talmud is lost. His major activity, however, was in Kabbalah. Zacuto opposed the mingling of the kabbalistic system of R. Cordovero with that of R. Isaac Luria which was then current in some circles (Tishby, in Zion, 22 (1957), 30) and for this reason he criticized R. Solomon Rocca's Sefer Kavvanat Shelomo (Venice, 1670) even though he composed a poem honoring the author (see Zacuto's Iggerot, letters nos. 7, 8). He went over the entire corpus of R. Luria's and R. Vital's writings and added many annotations under the name Kol ha-Re-Me-Z or the abbreviation Ma-Za-La-N (Moshe Zakkut Li Nireh - "It seems to me, Moses Zacuto"). Many of them are collected in the books Mekom Binah and Sha'arei Binah of R. Isaac Sabba (Salonika, 1812–13). Zacuto wrote at least two commentaries on the Zohar. Zacuto arranged tikkunim ("special prayers") for several religious ceremonies according to Kabbalah. These were often reprinted and had great influence, especially on the religious life in Italy. They include Sefer ha-Tikkunim (a tikkun for the eve of Shavuot and Hoshana Rabba; Venice, 1659), Mishmeret ha-Hodesh (ibid., 1660), Tikkun Shovavim (the initials of the first six sections of Exodus), i.e., a tikkun for fasts undertaken in expiation for nocturnal ejaculations (ibid., 1673), and Tikkun Hazot (ibid., 1704).

הסכמות: ,Isaac Vita Recanati, Paltiel Semah Isaque Vais Villa Real, Moise Correa Belmonte, Liorne, 16 Julho 1780 (פורטוגאלית); בית דין רבא דק"ק ליוורנו: ר' דוד מלאך, ר' דוד חיים חסאן ור' אליהו ב"ר משה הכהן, יד תמוז תר"ם. דף [2, ב - 3, א]: שיר ידידות, מאת משה אהרן פייאצה, הפותח: עובד שדה הלא ישמח/בראות גנו אשר נטע. עיין: אוצר השירה והפיוט, ג, עמ' 253, מס' 134.