R. Pardo's Hasdei David (Leghorn, 1776–90; Jerusalem, 1890) on the Tosefta is considered the most important commentary on this work (the portion on Tohorot, the manuscript of which is in the National Library of Jerusalem, has not been published). He completed the work in Jerusalem on his 68th birthday. Portions of it were published in the Romm Vilna edition of the Talmud with the text of the Tosefta. Similarly, his Sifrei de-Vei Rav (Salonika, 1799), which he commenced in 1786 and was published by his son Abraham after his death, is the most important commentary on the Sifrei. In it he makes use of commentaries of R. Hillel b. Eliakim, R. Solomon ibn Okhana, and R. Eliezer ibn Nahum, all of which he had in manuscript. Other works he wrote are Mikhtam le-David (Salonika, 1772), halakhic decisions and responsa; Maskil le-David (Venice, 1761), a supercommentary on Rashi's biblical commentary; La-Menazze'ah le-David (Salonika, 1765), on those talmudic passages where alternative explanations are given; Mizmor le-David (Leghorn, 1818), notes on the Perot Ginnosar of R. Hezekiah da Silva and R. Hayyim ibn Attar on Shulhan Arukh, Even ha-Ezer. R. Pardo's liturgical poems and prayers are included in the Sephardi daily and festival prayer books. His arrangement of the Avodah for the Day of Atonement, which was adopted in the Sephardi rite, appeared in his Shifat Revivim (Leghorn, 1788).

Of his sons, R. Jacob Pardo became chief rabbi of Ragusa and died in Jerusalem. He was a noted talmudist and well versed in Kabbalah. His chief works were Kohelet Ya'akov (Venice, 1784), a commentary on the early prophets; Appe Zutre (ibid., 1797), on Hilkhot Ishut of the Shulhan Arukh Even ha-Ezer, and Minhat Aharon (ibid., 1809), which deals mainly with the laws of prayer. A second son, R. Isaac, was rabbi of Sarajevo, while a third, R. Abraham, who married the daughter of R. H. J. D. Azulai, became head of the yeshivah Hesed le-Avraham u-Vinyan Shelomo after his father-in-law's death. R. Pardo's disciples included R. Shabbetai b. Abraham Ventura, who succeeded him as rabbi of Spalato, R. David Pinto, and R. Abraham Penso.